TMEM229B and PANX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM229B	PANX1
Description		transmembrane protein 229B	pannexin 1
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Bleb Protein-containing Complex
	Molecular Function	Protein Binding	Protease Binding Signaling Receptor Binding Structural Molecule Activity Calcium Channel Activity Protein Binding Wide Pore Channel Activity Leak Channel Activity Transmembrane Transporter Binding Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding
	Biological Process		Response To Ischemia Cation Transport Calcium Ion Transport Cell-cell Signaling Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Response To ATP Oogenesis Calcium Ion Transmembrane Transport
Pathways			Electric Transmission Across Gap Junctions The NLRP3 inflammasome
Drugs			Probenecid
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Glomerular filtration rate in chronic kidney disease ( 26420894) Glycerophospholipid levels ( 26068415) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 28892059) Refractive error ( 32231278) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352)	Alanine aminotransferase levels ( 33547301 34315874 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301 34315874 29403010 33339817) Autoimmune thyroid disease ( 32581359) Liver enzyme levels (alanine transaminase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		42 interacting genes: ACBD5 AQP6 ARL13B BIK CD53 CD79A CPLX4 CREB3L1 EBP ERGIC3 FAM209A FKBP7 GORAB GPX8 HSD17B13 ITGAM LHFPL5 MFF MFSD14B MGST3 MMGT1 MUC1 MYG1 NCR1 NEMP1 PANX1 PIGP PKMYT1 PVR REEP4 SEC22B SLC10A6 SLC39A2 SYT2 TLCD4 TMEM14B TMEM35A TMEM45B TMPRSS2 TSNARE1 VAPA VSIR	17 interacting genes: APOA2 APOL2 AQP2 BCL2L2 BUD31 CFHR5 CLCA4 FAXDC2 FDFT1 GNAS KEAP1 P2RX7 SLC38A7 TMEM229B TNF VAMP5 WFDC2
Entrez ID		161145	24145
HPRD ID		08157	10526
Ensembl ID		ENSG00000198133	ENSG00000110218
Uniprot IDs		A0A024R699 Q8NBD8	A0A024R397 Q96RD7
PDB IDs			6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN
Enriched GO Terms of Interacting Partners?
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