LIN52 and NEK9

		LIN52	NEK9
Description		lin-52 DREAM MuvB core complex component	NIMA related kinase 9
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GO Annotations	Cellular Component	Nucleoplasm DRM Complex	Nucleus Centrosome Cytosol
	Molecular Function	Protein Binding	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Transcription, DNA-templated	Protein Phosphorylation Cell Cycle Cell Division
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 28240269) Chronotype ( 30696823) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		8 interacting genes: DNAL1 DYRK1A EPM2AIP1 MAGEA6 MYBL2 NEK9 RBL2 RPS6KL1	21 interacting genes: BICD2 CSN2 GABARAP GZMB IFT43 JDP2 LIN52 MALL MAP1LC3B MBP NEK6 NEK7 NEK8 PALS1 RAN RARG RPS6KL1 SSRP1 SUPT16H TTN WDR33
Entrez ID		91750	91754
HPRD ID		18708	11386
Ensembl ID		ENSG00000205659	ENSG00000119638
Uniprot IDs		B3KN83 Q52LA3	A0A7I2V454 A0A7I2V5R1 Q6PKF2 Q8TD19
PDB IDs		4YOO 6C48	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?
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