LDB2 and LHX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LDB2	LHX8
Description		LIM domain binding 2	LIM homeobox 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Plasma Membrane Cell Leading Edge	Chromatin Female Germ Cell Nucleus Nucleus
	Molecular Function	Transcription Coregulator Activity Protein Binding Enzyme Binding LIM Domain Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Nervous System Development Epithelial Structure Maintenance Regulation Of Cell Migration Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Learning Or Memory Female Gonad Development Forebrain Neuron Development Neuron Differentiation Odontogenesis Of Dentin-containing Tooth
Pathways
Drugs
Diseases
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Liver fibrosis (total hepatic collagen content) ( 32953199) Number of sexual partners ( 30643258) QT interval ( 23534349) Rhegmatogenous retinal detachment ( 23585552) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference ( 28552196)
Interacting Genes		29 interacting genes: C14orf119 CETN3 DGCR6L EGLN3 EPM2AIP1 EXOC3L1 GGACT HDAC7 ISL1 LHX4 LHX8 LHX9 LMO1 LMO2 LMO3 LMO4 LNX1 NTAQ1 PSMB1 RASIP1 RILP RLIM SDCBP SMARCD1 SSBP2 SSBP3 SSBP4 TSNAX TTC19	27 interacting genes: - ABI2 ATF2 ATF6B AXIN1 BANP CCHCR1 CRK CSNK2A1 EFS FIGLA FOSL2 FOXN1 GINS4 KLF3 KRT85 LDB1 LDB2 NEDD9 NUTM1 PLCG2 PRPF31 SCYL3 SUV39H1 TBC1D1 TBC1D22B ZBTB24
Entrez ID		9079	431707
HPRD ID		16022	17275
Ensembl ID		ENSG00000169744	ENSG00000162624
Uniprot IDs		B7Z6D0 E9PFI4 G5E9Y7 O43679	Q68G74
PDB IDs
Enriched GO Terms of Interacting Partners?
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