LHX8 and TBC1D1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LHX8	TBC1D1
Description		LIM homeobox 8	TBC1 domain family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Female Germ Cell Nucleus Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Learning Or Memory Female Gonad Development Forebrain Neuron Development Neuron Differentiation Odontogenesis Of Dentin-containing Tooth	Intracellular Protein Transport Regulation Of Protein Localization Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Bipolar disorder ( 34099189) Crohn's disease ( 23850713 23266558) Diastolic blood pressure ( 27841878 27618452) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) High-sensitivity cardiac troponin T levels ( 33321125) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontal microbiota ( 22699663) Pulse pressure ( 27841878) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Systolic blood pressure ( 27841878 27618452) Verbal declarative memory ( 25648963) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		27 interacting genes: - ABI2 ATF2 ATF6B AXIN1 BANP CCHCR1 CRK CSNK2A1 EFS FIGLA FOSL2 FOXN1 GINS4 KLF3 KRT85 LDB1 LDB2 NEDD9 NUTM1 PLCG2 PRPF31 SCYL3 SUV39H1 TBC1D1 TBC1D22B ZBTB24	31 interacting genes: CALM1 CALM2 CALM3 CCDC185 CWF19L2 EFHC2 FAM161A FAM50B GABARAPL1 GMCL1 HOXC8 HSF2BP HSPB1 KRT75 L3MBTL3 LHX8 LNX1 LZTS1 MAP1LC3A MCRS1 PNKP RIN1 SMAD2 SYTL4 TCEA2 TNNC2 TSGA10IP TXLNA VPS52 YWHAG ZFP1
Entrez ID		431707	23216
HPRD ID		17275	18161
Ensembl ID		ENSG00000162624	ENSG00000065882
Uniprot IDs		Q68G74	B9A6J6 Q6PJJ8 Q86TI0 Q8NC59
PDB IDs			3QYE
Enriched GO Terms of Interacting Partners?
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