CCKBR and CCK

Number of citations of the paper that reports this interaction (PubMedID 15001692)
29

Data Source:
HPRD (in vivo, in vitro)

		CCKBR	CCK
Description		cholecystokinin B receptor	cholecystokinin
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Axon Dendrite Axon Initial Segment Terminal Bouton Axon Hillock Perikaryon
	Molecular Function	G Protein-coupled Receptor Activity Cholecystokinin Receptor Activity Protein Binding Gastrin Receptor Activity Peptide Hormone Binding Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Hormone Activity Neuropeptide Hormone Activity Protein Binding Peptide Hormone Receptor Binding
	Biological Process	Gastric Acid Secretion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Cholecystokinin Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity PH Reduction Digestive Tract Development Gland Development	Neuron Migration Release Of Cytochrome C From Mitochondria Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Digestion Memory Positive Regulation Of Cell Population Proliferation Visual Learning Positive Regulation Of Glutamate Secretion Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Appetite Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Eating Behavior Positive Regulation Of Sensory Perception Of Pain Negative Regulation Of Behavioral Fear Response Positive Regulation Of Behavioral Fear Response
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Pentagastrin Cholecystokinin	Camostat
Diseases
GWAS		Diastolic blood pressure ( 30224653) Early spontaneous preterm birth ( 31194736) Gastroesophageal reflux disease ( 31527586) Malaria ( 31844061) Rheumatic heart disease ( 34106200)	Adult body size ( 32376654) Body mass index ( 24348519 28892062 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (SNP x SNP interaction) ( 22344221) Body size at age 10 ( 32376654) Night sleep phenotypes ( 27126917)
Interacting Genes		10 interacting genes: ADRB2 ATP13A2 CCK CCKAR CCR4 DRD2 NTM PPP1R9B PTPN11 SLCO1B3	7 interacting genes: CCKAR CCKBR CPE ENPEP MEP1A MEP1B UBQLN2
Entrez ID		887	885
HPRD ID		00323	00321
Ensembl ID		ENSG00000110148	ENSG00000187094
Uniprot IDs		E9PIC8 P32239	P06307 Q6FG82
PDB IDs		1L4T
Enriched GO Terms of Interacting Partners?
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