CCKBR and SLCO1B3

Number of citations of the paper that reports this interaction (PubMedID 10320330)
6

Data Source:
BioGRID (pull down)

		CCKBR	SLCO1B3
Description		cholecystokinin B receptor	solute carrier organic anion transporter family member 1B3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Activity Cholecystokinin Receptor Activity Protein Binding Gastrin Receptor Activity Peptide Hormone Binding Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Organic Anion Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity
	Biological Process	Gastric Acid Secretion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Cholecystokinin Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity PH Reduction Digestive Tract Development Gland Development	Organic Anion Transport Bile Acid And Bile Salt Transport Heme Catabolic Process Sodium-independent Organic Anion Transport Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK	Recycling of bile acids and salts Heme degradation Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) Transport of organic anions
Drugs		Pentagastrin Cholecystokinin	Clarithromycin Gemfibrozil Ginsenoside Rb1 Ginsenoside Rg1
Diseases
GWAS		Diastolic blood pressure ( 30224653) Early spontaneous preterm birth ( 31194736) Gastroesophageal reflux disease ( 31527586) Malaria ( 31844061) Rheumatic heart disease ( 34106200)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Bilirubin levels ( 31801373 19419973 31319653 23371916 20639394) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Height ( 18391951) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Parkinson's disease progression (cognitive) ( 33111402) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total bilirubin levels ( 29403010)
Interacting Genes		10 interacting genes: ADRB2 ATP13A2 CCK CCKAR CCR4 DRD2 NTM PPP1R9B PTPN11 SLCO1B3	1 interacting genes: CCKBR
Entrez ID		887	28234
HPRD ID		00323	12021
Ensembl ID		ENSG00000110148	ENSG00000111700
Uniprot IDs		E9PIC8 P32239	B3KP78 Q9NPD5
PDB IDs		1L4T
Enriched GO Terms of Interacting Partners?
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