DPM2 and PIGC

Number of citations of the paper that reports this interaction (PubMedID 10944123)
41

Data Source:
HPRD (in vitro)

		DPM2	PIGC
Description		dolichyl-phosphate mannosyltransferase subunit 2, regulatory	phosphatidylinositol glycan anchor biosynthesis class C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Regulator Activity	Catalytic Activity Protein Binding
	Biological Process	GPI Anchor Biosynthetic Process Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Regulation Of Catalytic Activity	GPI Anchor Biosynthetic Process
Pathways		Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)	Body shape index ( 34021172) Daytime sleep phenotypes ( 27126917) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		7 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC SLC22A2 VKORC1	5 interacting genes: DPM2 KLF10 PIGQ SERPINC1 ZHX1
Entrez ID		8818	5279
HPRD ID		16028	03433
Ensembl ID		ENSG00000136908	ENSG00000135845
Uniprot IDs		O94777	Q92535
PDB IDs
Enriched GO Terms of Interacting Partners?
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