DPM2 and HLA-DMB

Number of citations of the paper that reports this interaction (PubMedID 11591653)
42

Data Source:
HPRD (in vivo)

		DPM2	HLA-DMB
Description		dolichyl-phosphate mannosyltransferase subunit 2, regulatory	major histocompatibility complex, class II, DM beta
Image		No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex	Lysosomal Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Regulator Activity	Protein Binding MHC Class II Protein Complex Binding
	Biological Process	GPI Anchor Biosynthetic Process Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Regulation Of Catalytic Activity	Adaptive Immune Response Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response MHC Class II Protein Complex Assembly Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways		Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)	MHC class II antigen presentation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Body shape index ( 34021172) Dermatomyositis ( 27153935) Lung cancer ( 28604730) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 30285260) Squamous cell lung carcinoma ( 28604730) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC SLC22A2 VKORC1	11 interacting genes: CD63 CD74 CD82 CUL3 DPM2 HLA-DMA HLA-DOB HLA-DRA MDM2 PSEN2 TEAD1
Entrez ID		8818	3109
HPRD ID		16028	00831
Ensembl ID		ENSG00000136908	ENSG00000242574
Uniprot IDs		O94777	A0A1V0E3P2 P28068
PDB IDs			1HDM 2BC4 4FQX 4GBX 4I0P
Enriched GO Terms of Interacting Partners?
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