SUCLA2 and ALAS2

Number of citations of the paper that reports this interaction (PubMedID 10727444)
20

Data Source:
HPRD (in vivo)

		SUCLA2	ALAS2
Description		succinate-CoA ligase ADP-forming subunit beta	5'-aminolevulinate synthase 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Succinate-CoA Ligase Complex Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Magnesium Ion Binding Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity Protein Binding ATP Binding	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding
	Biological Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Succinyl-CoA Pathway	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Cellular Iron Ion Homeostasis Erythrocyte Differentiation Oxygen Homeostasis Hemoglobin Biosynthetic Process Erythrocyte Development
Pathways		Citric acid cycle (TCA cycle)	Heme biosynthesis
Drugs			Pyridoxal phosphate Glycine
Diseases
GWAS		Aging (time to event) ( 21782286) Colorectal cancer (diet interaction) ( 24743840) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Serum metabolite levels ( 33031748) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		11 interacting genes: AGTRAP ALAS2 ARL6IP1 CMTM5 FAM9B FKBP7 MAGEA11 MAL2 MTNR1A SEC23A TNFRSF10D	4 interacting genes: BANP GRB2 RABGGTB SUCLA2
Entrez ID		8803	212
HPRD ID		06798	02356
Ensembl ID		ENSG00000136143	ENSG00000158578
Uniprot IDs		E5KS60 Q9P2R7 Q9Y4T0	P22557
PDB IDs		6G4Q	5QQQ 5QQR 5QQS 5QQT 5QQU 5QQV 5QQW 5QQX 5QQY 5QQZ 5QR0 5QR1 5QR2 5QR3 5QR4 5QR5 5QR6 5QR7 5QR8 5QR9 5QRA 5QRB 5QRC 5QRD 5QRE 5QT3 6HRH
Enriched GO Terms of Interacting Partners?
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