ALAS2 and SUCLA2

Number of citations of the paper that reports this interaction (PubMedID 10727444)
20

Data Source:
HPRD (in vivo)

		ALAS2	SUCLA2
Description		5'-aminolevulinate synthase 2	succinate-CoA ligase ADP-forming subunit beta
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix Succinate-CoA Ligase Complex Extracellular Exosome
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding	Magnesium Ion Binding Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity Protein Binding ATP Binding
	Biological Process	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Cellular Iron Ion Homeostasis Erythrocyte Differentiation Oxygen Homeostasis Hemoglobin Biosynthetic Process Erythrocyte Development	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Succinyl-CoA Pathway
Pathways		Heme biosynthesis	Citric acid cycle (TCA cycle)
Drugs		Pyridoxal phosphate Glycine
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)	Aging (time to event) ( 21782286) Colorectal cancer (diet interaction) ( 24743840) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Serum metabolite levels ( 33031748) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		4 interacting genes: BANP GRB2 RABGGTB SUCLA2	11 interacting genes: AGTRAP ALAS2 ARL6IP1 CMTM5 FAM9B FKBP7 MAGEA11 MAL2 MTNR1A SEC23A TNFRSF10D
Entrez ID		212	8803
HPRD ID		02356	06798
Ensembl ID		ENSG00000158578	ENSG00000136143
Uniprot IDs		P22557	E5KS60 Q9P2R7 Q9Y4T0
PDB IDs		5QQQ 5QQR 5QQS 5QQT 5QQU 5QQV 5QQW 5QQX 5QQY 5QQZ 5QR0 5QR1 5QR2 5QR3 5QR4 5QR5 5QR6 5QR7 5QR8 5QR9 5QRA 5QRB 5QRC 5QRD 5QRE 5QT3 6HRH	6G4Q
Enriched GO Terms of Interacting Partners?
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