DYRK4 and CUL3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		DYRK4	CUL3
Description		dual specificity tyrosine phosphorylation regulated kinase 4	cullin 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Intracellular Membrane-bounded Organelle	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Polar Microtubule Cytosol Plasma Membrane Membrane Cullin-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Sperm Flagellum Extracellular Exosome Mitotic Spindle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Notch Binding Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Positive Regulation Of Cell Population Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Cell Projection Organization Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fibroblast Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Protein Autoubiquitination Protein K48-linked Ubiquitination Nuclear Protein Quality Control By The Ubiquitin-proteasome System Liver Morphogenesis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Phase Transition
Pathways			Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs ROS sensing by NFE2L2 ROS sensing by NFE2L2 Neddylation RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Allergic rhinitis ( 25085501)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Age at first sexual intercourse ( 34211149) General risk tolerance (MTAG) ( 30643258) Response to bupropion and depression ( 27622933) Schizophrenia ( 28991256 25056061 29483656 30285260) Sensorimotor dexterity ( 31596458) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		6 interacting genes: CUL3 DYRK2 FBXO25 MID1 NEDD4 PPP1CC	82 interacting genes: ABTB1 ABTB2 ACLY AGFG1 APP ARHGEF12 BTBD1 BTBD10 BTBD2 BTBD3 BTBD6 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 CLK1 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 DYRK4 EFNB1 ELOC FAM124B FOLR1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GPS1 GYPA HLA-DMB HSF2 KCTD10 KCTD11 KCTD13 KCTD17 KCTD5 KCTD6 KCTD7 KCTD9 KLHL12 KLHL2 KLHL3 KLHL42 MAP1LC3B MAP1LC3C MAT2A MTNR1A MTNR1B NDUFA10 NEDD8 OLIG2 PDCD6 PDIA2 PEF1 RBBP8 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SPOP SRA1 SUMO2 SUMO3 UBASH3B UBC UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2E3 WNT7B ZAP70 ZMAT4
Entrez ID		8798	8452
HPRD ID		10926	09123
Ensembl ID		ENSG00000010219	ENSG00000036257
Uniprot IDs		B4E1A4 D3JEN2 Q9NR20	A0A024R475 B7Z600 Q13618
PDB IDs			2MYL 2MYM 4AP2 4APF 4EOZ 4HXI 5NLB 6I2M
Enriched GO Terms of Interacting Partners?
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