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CUL3 and UBASH3B
Number of citations of the paper that reports this interaction (PubMedID
26766443
)
10
Data Source:
BioGRID
(pull down)
CUL3
UBASH3B
Description
cullin 3
ubiquitin associated and SH3 domain containing B
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Polar Microtubule
Cytosol
Plasma Membrane
Membrane
Cullin-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Sperm Flagellum
Extracellular Exosome
Mitotic Spindle
Nucleus
Cytoplasm
Molecular Function
Ubiquitin-protein Transferase Activity
Notch Binding
Protein Binding
Cyclin Binding
POZ Domain Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Trophectodermal Cellular Morphogenesis
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Mitotic Metaphase Plate Congression
Integrin-mediated Signaling Pathway
Gastrulation
Positive Regulation Of Cell Population Proliferation
Wnt Signaling Pathway
Cell Migration
Protein Ubiquitination
Stem Cell Division
Cell Projection Organization
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Positive Regulation Of Cytokinesis
Negative Regulation Of Rho Protein Signal Transduction
Embryonic Cleavage
Stress Fiber Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Fibroblast Apoptotic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
COPII Vesicle Coating
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Liver Morphogenesis
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Protein Kinase Activity
Negative Regulation Of Signal Transduction
Peptidyl-tyrosine Dephosphorylation
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Regulation Of Protein Binding
Regulation Of Osteoclast Differentiation
Negative Regulation Of Osteoclast Differentiation
Negative Regulation Of Bone Resorption
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Platelet Aggregation
Negative Regulation Of Platelet Aggregation
Pathways
Degradation of DVL
Hedgehog 'on' state
Regulation of RAS by GAPs
ROS sensing by NFE2L2
ROS sensing by NFE2L2
Neddylation
RHOBTB2 GTPase cycle
RHOBTB1 GTPase cycle
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Acute graft versus host disease in bone marrow transplantation (recipient effect) (
27595289
)
Age at first sexual intercourse (
34211149
)
General risk tolerance (MTAG) (
30643258
)
Response to bupropion and depression (
27622933
)
Schizophrenia (
28991256
25056061
29483656
30285260
)
Sensorimotor dexterity (
31596458
)
Thrombin-activatable fibrinolysis inhibitor activation peptide (
29378355
)
Apolipoprotein A1 levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Blood urea nitrogen levels (
31152163
)
Cholesterol, total (
24097068
25961943
20686565
)
Chronotype (
30696823
)
Diastolic blood pressure (
30224653
)
Eye length (
30174134
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
HDL cholesterol (
24097068
20686565
)
HDL cholesterol levels (
32203549
)
High density lipoprotein cholesterol levels (
33339817
)
High light scatter reticulocyte percentage of red cells (
32888494
)
LDL cholesterol levels (
32203549
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Pemphigus vulgaris (
29857070
)
Serum immune biomarker levels (
32066700
)
Stroke (
26089329
)
Systolic blood pressure (
30578418
)
Total cholesterol levels (
28334899
)
Interacting Genes
82 interacting genes:
ABTB1
ABTB2
ACLY
AGFG1
APP
ARHGEF12
BTBD1
BTBD10
BTBD2
BTBD3
BTBD6
CAMK1D
CAND1
CCND1
CCNE1
CDC25A
CDC34
CLK1
COMMD1
COPS5
DCUN1D2
DCUN1D3
DCUN1D4
DCUN1D5
DYRK4
EFNB1
ELOC
FAM124B
FOLR1
GABARAP
GABARAPL1
GABARAPL2
GMCL1
GPS1
GYPA
HLA-DMB
HSF2
KCTD10
KCTD11
KCTD13
KCTD17
KCTD5
KCTD6
KCTD7
KCTD9
KLHL12
KLHL2
KLHL3
KLHL42
MAP1LC3B
MAP1LC3C
MAT2A
MTNR1A
MTNR1B
NDUFA10
NEDD8
OLIG2
PDCD6
PDIA2
PEF1
RBBP8
RBX1
RCBTB1
RCBTB2
RHOBTB3
RIT1
RNF7
SHKBP1
SPOP
SRA1
SUMO2
SUMO3
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2E1
UBE2E2
UBE2E3
WNT7B
ZAP70
ZMAT4
51 interacting genes:
BBC3
CBL
CBLB
CCDC74B
CUL3
DAZAP2
DISC1
DLGAP2
DMRT3
DOC2A
DTX3
EFS
FAM168A
HOXB2
INCA1
JAK2
KAT5
KDM1A
KHDRBS1
KPRP
LMO2
LZTS2
MAP3K1
PIAS2
PKP4
PRKN
PRR35
PSMB1
PTPN21
RCHY1
REL
RNF216
RNF41
SHC1
SLC25A48
SPRY2
SYK
TCF4
TEPSIN
TNKS
TP53BP2
UBB
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
VPS37B
WASL
Entrez ID
8452
84959
HPRD ID
09123
16463
Ensembl ID
ENSG00000036257
ENSG00000154127
Uniprot IDs
A0A024R475
B7Z600
Q13618
Q8TF42
PDB IDs
2MYL
2MYM
4AP2
4APF
4EOZ
4HXI
5NLB
6I2M
2CPW
2E5K
5VR6
5W5G
Enriched GO Terms of Interacting Partners
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