MPDZ and CSPG4

Number of citations of the paper that reports this interaction (PubMedID 10967549)
27

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		MPDZ	CSPG4
Description		multiple PDZ domain crumbs cell polarity complex component	chondroitin sulfate proteoglycan 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Bicellular Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Apical Part Of Cell	Ruffle Extracellular Region Nucleoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Apical Plasma Membrane Lamellipodium Membrane Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding	Coreceptor Activity Protein Kinase Binding
	Biological Process	Microtubule Organizing Center Organization Regulation Of Microtubule Cytoskeleton Organization Tight Junction Assembly	Angiogenesis Substrate-dependent Cell Migration Cell Population Proliferation Glial Cell Migration Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Platelet-derived Growth Factor Receptor Signaling Pathway Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Ruffle Assembly
Pathways			A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS		Central corneal thickness ( 32528159 29760442) Corneal hysteresis ( 32716492 30894546) Corneal structure ( 23291589) Heel bone mineral density ( 30598549 28869591) Refractive astigmatism ( 30306274) Triglyceride levels ( 32203549)	Estimated glomerular filtration rate ( 31015462) Hip index ( 34021172) Intraocular pressure ( 29617998) Simvastatin-induced myopathy ( 31220337)
Interacting Genes		16 interacting genes: ABCA1 CAMK2A CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2	9 interacting genes: ATF7IP BCAR1 C1QA CDC42 GRIP1 GRIP2 MPDZ PTK2 TNK2
Entrez ID		8777	1464
HPRD ID		09155	03105
Ensembl ID		ENSG00000107186	ENSG00000173546
Uniprot IDs		O75970	Q6UVK1
PDB IDs		2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?
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