EIF3I and IPO13

		EIF3I	IPO13
Description		eukaryotic translation initiation factor 3 subunit I	importin 13
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	Protein Binding Small GTPase Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translational Initiation	Protein Import Into Nucleus
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
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Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		14 interacting genes: EIF3A EIF3B EIF4G1 ERCC6 ESR1 EXOSC6 IPO13 KDM4A LIG4 METTL3 PAXIP1 SUMO4 TGFB1 TGFBR2	28 interacting genes: ALX1 ARX CDK1 CRX EIF1AX EIF2B3 EIF3I EIF4B GK HMBOX1 KDM4A MAGOH MAST2 NPSR1 NUP50 PAX3 PAX6 PBX4 PIK3R3 PITX1 PPFIA2 PPIH PREX1 PSMA1 RAN RBM8A RPL5 UBE2I
Entrez ID		8668	9670
HPRD ID		04884	13742
Ensembl ID		ENSG00000084623	ENSG00000117408
Uniprot IDs		Q13347 Q5U0F4	O94829
PDB IDs		6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09	2X19 2XWU 3ZJY
Enriched GO Terms of Interacting Partners?
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