IPO13 and EIF4B

		IPO13	EIF4B
Description		importin 13	eukaryotic translation initiation factor 4B
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Dendrite Neuronal Cell Body Postsynapse
	Molecular Function	Protein Binding Small GTPase Binding	RNA Binding Translation Initiation Factor Activity Protein Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding
	Biological Process	Protein Import Into Nucleus	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Assembly
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
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Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 21743057)
Interacting Genes		28 interacting genes: ALX1 ARX CDK1 CRX EIF1AX EIF2B3 EIF3I EIF4B GK HMBOX1 KDM4A MAGOH MAST2 NPSR1 NUP50 PAX3 PAX6 PBX4 PIK3R3 PITX1 PPFIA2 PPIH PREX1 PSMA1 RAN RBM8A RPL5 UBE2I	19 interacting genes: ACD CASP3 CSNK2A1 EIF3A EIF4E IPO13 LAMTOR5 LINC01554 PABPC1 PAK2 POT1 RHOU RPS6KB1 SFN SMAD3 SRPK2 TERF1 TINF2 USP11
Entrez ID		9670	1975
HPRD ID		13742	04892
Ensembl ID		ENSG00000117408	ENSG00000063046
Uniprot IDs		O94829	B4DRM3 E7EX17 P23588 Q7Z5Y0
PDB IDs		2X19 2XWU 3ZJY	1WI8 2J76 6FEC
Enriched GO Terms of Interacting Partners?
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