EIF3F and EML2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EIF3F	EML2
Description		eukaryotic translation initiation factor 3 subunit F	EMAP like 2
Image
GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytoplasm Microtubule Microtubule Associated Complex Mitotic Spindle
	Molecular Function	Translation Initiation Factor Activity Thiol-dependent Deubiquitinase Protein Binding Metallopeptidase Activity Translation Initiation Factor Binding Identical Protein Binding Isopeptidase Activity Deubiquitinase Activity	Signaling Receptor Binding Protein Binding Microtubule Binding Protein C-terminus Binding Tubulin Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Protein Deubiquitination IRES-dependent Viral Translational Initiation	Microtubule Cytoskeleton Organization Visual Perception Sensory Perception Of Sound Regulation Of Microtubule Nucleation Negative Regulation Of Microtubule Polymerization
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs		Quercetin
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depression (quantitative trait) ( 20800221) Malaria ( 31844061) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Fruit consumption ( 32066663) Hemoglobin A1c levels ( 29403010) Subcutaneous adipose tissue ( 22589738) Type 2 diabetes ( 32499647)
Interacting Genes		45 interacting genes: AGR2 APP ATXN1 C1orf216 C6orf201 CCDC120 CCDC196 CDC42 CDK11A CDK11B CDK19 CDSN COL1A2 DKC1 EEF1A1 EIF3M EML2 ERCC6 FBXO32 HAX1 HGS HNRNPK HTR2A MCPH1 MKRN2 MSH4 MTOR MYDGF MYOZ1 NUP54 OGT PBX4 PKN1 POGZ POU6F2 PTN RABIF RIN1 RPS6KB1 RTP5 SHBG SMAD9 SUOX TIMM10B WASHC1	13 interacting genes: BPIFA1 EIF3F EXD1 IFI35 IFT88 KLHDC2 PLEKHF2 PTTG2 REL RFC5 SNX32 SPANXA1 SPANXA2
Entrez ID		8665	24139
HPRD ID		04887	16860
Ensembl ID		ENSG00000175390	ENSG00000125746
Uniprot IDs		O00303	O95834
PDB IDs		3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09	4CGB
Enriched GO Terms of Interacting Partners?
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