ALDH4A1 and ARG1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ALDH4A1	ARG1
Description		aldehyde dehydrogenase 4 family member A1	arginase 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrial Outer Membrane Cytosol Azurophil Granule Lumen Specific Granule Lumen Neuron Projection Neuronal Cell Body
	Molecular Function	1-pyrroline-5-carboxylate Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Protein Binding Electron Transfer Activity Identical Protein Binding	Arginase Activity Protein Binding Manganese Ion Binding Identical Protein Binding
	Biological Process	Proline Metabolic Process Proline Catabolic Process Proline Catabolic Process To Glutamate 4-hydroxyproline Catabolic Process Electron Transport Chain	Urea Cycle Liver Development Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Arginine Catabolic Process Aging Response To Xenobiotic Stimulus Response To Herbicide Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Regulation Of L-arginine Import Response To Amine Arginine Catabolic Process To Ornithine Lung Development Collagen Biosynthetic Process Response To Vitamin A Response To Vitamin E Negative Regulation Of T Cell Proliferation Defense Response To Protozoan Response To Amino Acid Innate Immune Response Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Response To Axon Injury Response To Methylmercury Mammary Gland Involution Maternal Process Involved In Female Pregnancy Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of Neutrophil Mediated Killing Of Fungus Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Glyoxylate metabolism and glycine degradation Proline catabolism	Neutrophil degranulation Urea cycle
Drugs		NADH	Ornithine 2(S)-Amino-6-Boronohexanoic Acid nor-NOHA Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine Manganese
Diseases
GWAS		Alzheimer's disease (survival time) ( 25649651) Anorexia nervosa ( 23568457) Metabolite levels ( 23823483)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) C-reactive protein levels ( 24763700) Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) HDL cholesterol levels ( 32203549) Obesity ( 21552555) Serum metabolite levels ( 33031748) Type 2 diabetes ( 30054458)
Interacting Genes		3 interacting genes: APP ARG1 OGT	6 interacting genes: ALDH4A1 ARG2 CDC42 FLOT1 NOS1 UCHL5
Entrez ID		8659	383
HPRD ID		06009	01947
Ensembl ID		ENSG00000159423	ENSG00000118520
Uniprot IDs		A0A024RAC7 P30038	P05089
PDB IDs		3V9G 3V9H 3V9I 4OE5	1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1 6Q92 6Q9P 6QAF 6V7C 6V7D 6V7E 6V7F
Enriched GO Terms of Interacting Partners?
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