ARG1 and ARG2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ARG1	ARG2
Description		arginase 1	arginase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrial Outer Membrane Cytosol Azurophil Granule Lumen Specific Granule Lumen Neuron Projection Neuronal Cell Body	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Arginase Activity Protein Binding Manganese Ion Binding Identical Protein Binding	Arginase Activity Protein Binding Manganese Ion Binding
	Biological Process	Urea Cycle Liver Development Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Arginine Catabolic Process Aging Response To Xenobiotic Stimulus Response To Herbicide Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Regulation Of L-arginine Import Response To Amine Arginine Catabolic Process To Ornithine Lung Development Collagen Biosynthetic Process Response To Vitamin A Response To Vitamin E Negative Regulation Of T Cell Proliferation Defense Response To Protozoan Response To Amino Acid Innate Immune Response Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Response To Axon Injury Response To Methylmercury Mammary Gland Involution Maternal Process Involved In Female Pregnancy Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of Neutrophil Mediated Killing Of Fungus Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of T-helper 2 Cell Cytokine Production	Urea Cycle Ureteric Bud Development Adaptive Immune Response Negative Regulation Of Type 2 Immune Response Nitric Oxide Biosynthetic Process Striated Muscle Contraction Arginine Catabolic Process To Ornithine Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Tumor Necrosis Factor Production Innate Immune Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 4 Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of Defense Response To Bacterium Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Cellular Senescence
Pathways		Neutrophil degranulation Urea cycle	Urea cycle
Drugs		Ornithine 2(S)-Amino-6-Boronohexanoic Acid nor-NOHA Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine Manganese	Arginine Ornithine S-2-(Boronoethyl)-L-Cysteine
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) C-reactive protein levels ( 24763700) Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) HDL cholesterol levels ( 32203549) Obesity ( 21552555) Serum metabolite levels ( 33031748) Type 2 diabetes ( 30054458)
Interacting Genes		6 interacting genes: ALDH4A1 ARG2 CDC42 FLOT1 NOS1 UCHL5	3 interacting genes: ARG1 DCC STK11
Entrez ID		383	384
HPRD ID		01947	00143
Ensembl ID		ENSG00000118520	ENSG00000081181
Uniprot IDs		P05089	A0A024R6A0 P78540
PDB IDs		1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1 6Q92 6Q9P 6QAF 6V7C 6V7D 6V7E 6V7F	1PQ3 4HZE 4I06 4IE2 4IE3 4IXU 4IXV 6Q37 6Q39 6SS2 6SS4 6SS6
Enriched GO Terms of Interacting Partners?
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