PRKRA and STAU1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid, proximity labelling technology, affinity chromatography technology)

		PRKRA	STAU1
Description		protein activator of interferon induced protein kinase EIF2AK2	staufen double-stranded RNA binding protein 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm RISC-loading Complex	Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Microtubule Associated Complex Plasma Membrane Cytoplasmic Stress Granule Membrane Dendrite Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Cell Body Extracellular Exosome Glutamatergic Synapse
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding	RNA Binding Double-stranded RNA Binding Protein Binding Protein Phosphatase 1 Binding
	Biological Process	Protein Phosphorylation Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus Production Of SiRNA Involved In RNA Interference Pre-miRNA Processing Cellular Response To Oxidative Stress Production Of MiRNAs Involved In Gene Silencing By MiRNA Outer Ear Morphogenesis Middle Ear Morphogenesis Skeletal System Morphogenesis Regulation Of Catalytic Activity Protein Stabilization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cellular Response To Oxidative Stress Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Modification Of Postsynaptic Structure Positive Regulation Of Long-term Synaptic Potentiation
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS		Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)	Anger ( 24489884) Change in quality of life in response to fluticasone propionate/salmeterol in chronic obstructive pulmonary disease ( 31299468) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 32581322) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196 25282103) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		34 interacting genes: ADARB1 AGO2 CAT CEBPZ CEP126 CLASP1 COPS6 DICER1 EHHADH EIF2AK2 FZD7 GDF9 HEYL LNX1 LYAR NKRF PIAS2 PITPNM1 PLEKHA3 POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 STAU1 STRBP TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZMAT4 ZNF746	45 interacting genes: ADARB1 APP CASC3 CDC42 CSNK2B DHX9 DYNC1I1 FMR1 GLRX3 HNRNPU INA IQGAP1 KIF2B LONRF1 MAP1B MAPT MYH1 NCBP1 NCL NKRF NXT1 OGT PABPC1 PABPN1 PPP1CA PPP1CC PRKRA RAC1 RASA1 ROCK2 RPL28 RPL6 RPL7A RPLP0 RPS6 SPP1 SRPK1 STRBP TAX1BP3 TINCR TUBB TUBB4A UBE2D3 UPF1 ZMAT3
Entrez ID		8575	6780
HPRD ID		04573	03422
Ensembl ID		ENSG00000180228	ENSG00000124214
Uniprot IDs		A0A7I2V2I8 B4DJC7 O75569	B3KRE0 O95793 Q59F99 Q6PJX3
PDB IDs		2DIX	4DKK 6HTU 6SDW 6SDY
Enriched GO Terms of Interacting Partners?
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