PRKRA and DICER1

Number of citations of the paper that reports this interaction (PubMedID 16424907)
255

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		PRKRA	DICER1
Description		protein activator of interferon induced protein kinase EIF2AK2	dicer 1, ribonuclease III
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm RISC-loading Complex	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol RISC Complex Dendrite Growth Cone ARC Complex Perinuclear Region Of Cytoplasm Extracellular Exosome RISC-loading Complex
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding	DNA Binding RNA Binding Double-stranded RNA Binding Helicase Activity Endoribonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding Protein Domain Specific Binding SiRNA Binding Metal Ion Binding Pre-miRNA Binding
	Biological Process	Protein Phosphorylation Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus Production Of SiRNA Involved In RNA Interference Pre-miRNA Processing Cellular Response To Oxidative Stress Production Of MiRNAs Involved In Gene Silencing By MiRNA Outer Ear Morphogenesis Middle Ear Morphogenesis Skeletal System Morphogenesis Regulation Of Catalytic Activity Protein Stabilization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation MiRNA Metabolic Process Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Schwann Cell Differentiation TRNA Catabolic Process Nerve Development Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Negative Regulation Of Tumor Necrosis Factor Production Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference SiRNA Loading Onto RISC Involved In RNA Interference Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Conversion Of Ds SiRNA To Ss SiRNA NIK/NF-kappaB Signaling Neuron Projection Morphogenesis RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis
Drugs
Diseases
GWAS		Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)	Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549 28869591) Metabolite levels ( 23823483) Nose size ( 27182965) Plasma anti-thyroid peroxidase levels ( 29678681) Response to statin therapy ( 20339536)
Interacting Genes		34 interacting genes: ADARB1 AGO2 CAT CEBPZ CEP126 CLASP1 COPS6 DICER1 EHHADH EIF2AK2 FZD7 GDF9 HEYL LNX1 LYAR NKRF PIAS2 PITPNM1 PLEKHA3 POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 STAU1 STRBP TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZMAT4 ZNF746	12 interacting genes: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2 TRIM25
Entrez ID		8575	23405
HPRD ID		04573	05875
Ensembl ID		ENSG00000180228	ENSG00000100697
Uniprot IDs		A0A7I2V2I8 B4DJC7 O75569	Q9UPY3
PDB IDs		2DIX	2EB1 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA 4WYQ 5ZAK 5ZAL 5ZAM
Enriched GO Terms of Interacting Partners?
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