AP3B1 and CSNK1A1

Number of citations of the paper that reports this interaction (PubMedID 12062430)
8

Data Source:
HPRD (in vivo, in vitro)

		AP3B1	CSNK1A1
Description		adaptor related protein complex 3 subunit beta 1	casein kinase 1 alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Membrane Synapse Axon Cytoplasm	Kinetochore Nucleus Cytoplasm Centrosome Cytosol Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Keratin Filament
	Molecular Function	Protein Binding Protein Phosphatase Binding GTP-dependent Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Cell Morphogenesis Toll-like Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Respiratory System Process Cellular Protein Modification Process Protein Targeting To Lysosome Cellular Zinc Ion Homeostasis Intracellular Protein Transport Inflammatory Response Lysosome Organization Spermatogenesis Single Fertilization Blood Coagulation Anterograde Axonal Transport Synaptic Vesicle Budding From Endosome Vesicle-mediated Transport Granulocyte Differentiation Melanosome Organization Protein Localization To Cell Surface MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Regulation Of Catalytic Activity Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Lung Morphogenesis Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Skin Epidermis Development	Protein Phosphorylation Golgi Organization Cell Cycle Signal Transduction Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Peptidyl-serine Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of GTP Binding
Pathways		Golgi Associated Vesicle Biogenesis Signaling by BRAF and RAF1 fusions	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO Maturation of nucleoprotein
Drugs			Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Body size at age 10 ( 32376654) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) FEV1 ( 30804560) Hip circumference adjusted for BMI ( 34021172) Insulin resistance/response ( 21901158) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609 30804560) Metabolite levels ( 23823483) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 26780889) Type 2 diabetes ( 31049640)	Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)
Interacting Genes		19 interacting genes: AP3D1 AP3S2 ARF1 ARF5 ARF6 ARR3 ATM ATR BUB1 BUB1B CLTC CSNK1A1 CXADR FCGR2B GKAP1 RNGTT SLC30A3 SSBP2 ZER1	48 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CRBN CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 UVRAG YWHAQ YWHAZ ZRANB1
Entrez ID		8546	1452
HPRD ID		04551	02739
Ensembl ID		ENSG00000132842	ENSG00000113712
Uniprot IDs		A0A0S2Z5J4 O00203	B4DER9 P48729 Q6PJ06
PDB IDs			5FQD 6GZD
Enriched GO Terms of Interacting Partners?
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