CSNK1A1 and NFATC3

Number of citations of the paper that reports this interaction (PubMedID 26186194)
524

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		CSNK1A1	NFATC3
Description		casein kinase 1 alpha 1	nuclear factor of activated T cells 3
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Centrosome Cytosol Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Keratin Filament	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation Golgi Organization Cell Cycle Signal Transduction Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Peptidyl-serine Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of GTP Binding	Cytokine Production Regulation Of Transcription By RNA Polymerase II Inflammatory Response Calcineurin-NFAT Signaling Cascade Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO Maturation of nucleoprotein	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation
Drugs		Fostamatinib
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)	Chronotype ( 30696823) Estimated glomerular filtration rate ( 31015462) Fasting glucose ( 33402679) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528)
Interacting Genes		48 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CRBN CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 UVRAG YWHAQ YWHAZ ZRANB1	13 interacting genes: CALB2 CDK6 CELSR2 CSNK1A1 FOS KCNJ3 MAPK8 MAPK9 MYOCD SEC24A SNX20 TOR1B TTF1
Entrez ID		1452	4775
HPRD ID		02739	04077
Ensembl ID		ENSG00000113712	ENSG00000072736
Uniprot IDs		B4DER9 P48729 Q6PJ06	B5B2S0 B5B2S1 Q12968
PDB IDs		5FQD 6GZD	2XRW 2XS0
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?