ATOH8 and CYP3A5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ATOH8	CYP3A5
Description		atonal bHLH transcription factor 8	cytochrome P450 family 3 subfamily A member 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxygen Binding Heme Binding Testosterone 6-beta-hydroxylase Activity Aromatase Activity Estrogen 16-alpha-hydroxylase Activity
	Biological Process	Formation Of Primary Germ Layer Negative Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Neuron Differentiation Tube Formation Positive Regulation Of Endothelial Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Myoblast Proliferation SMAD Protein Signal Transduction Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Lipid Hydroxylation Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Alkaloid Catabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Aflatoxin Metabolic Process Oxidative Demethylation
Pathways			Xenobiotics Aflatoxin activation and detoxification
Drugs			Cannabidiol Diacerein Nabiximols
Diseases
GWAS		Blood metabolite levels ( 31502714) Optic disc size ( 31809533)	Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Platelet count ( 29403010) Serum metabolite levels ( 33031748 23093944) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		1 interacting genes: CYP3A5	3 interacting genes: ATOH8 ETV5 RDH13
Entrez ID		84913	1577
HPRD ID		09813	05617
Ensembl ID		ENSG00000168874	ENSG00000106258
Uniprot IDs		Q96SQ7	B7Z3P6 P20815
PDB IDs			5VEU
Enriched GO Terms of Interacting Partners?
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