LINGO1 and RTN4R

Number of citations of the paper that reports this interaction (PubMedID 14966521)
241

Data Source:
HPRD (in vitro, in vivo)

		LINGO1	RTN4R
Description		leucine rich repeat and Ig domain containing 1	reticulon 4 receptor
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Matrix	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Anchored Component Of External Side Of Plasma Membrane Neuron Projection Neuronal Cell Body Dendritic Shaft Perikaryon Axonal Growth Cone Membrane Raft Extracellular Exosome Presynapse Glutamatergic Synapse
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding	Protein Binding Heparin Binding Chondroitin Sulfate Binding Signaling Receptor Activity Neuregulin Receptor Activity Protein-containing Complex Binding Ganglioside GM1 Binding Ganglioside GT1b Binding
	Biological Process		Cell Surface Receptor Signaling Pathway Axonogenesis Negative Regulation Of Neuron Projection Development Corpus Callosum Development Neuronal Signal Transduction Negative Regulation Of Axon Extension Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axon Regeneration
Pathways		Axonal growth inhibition (RHOA activation)	Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Adult body size ( 32376654) Caffeine consumption from coffee or tea ( 33287642) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Essential tremor ( 19182806) Feeling miserable ( 29500382) General factor of neuroticism ( 30867560) Hemoglobin A1c levels ( 29403010) High density lipoprotein cholesterol levels ( 33339817) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neuroticism ( 27089181) Risky sexual behaviors (alcohol dependence interaction) ( 28990359) Systemic lupus erythematosus ( 33536424) Triglyceride levels ( 32902719)	Blood protein levels ( 30072576 29875488) Obesity-related traits ( 23251661)
Interacting Genes		18 interacting genes: EFEMP2 FBLN1 FBXW7 FRS3 GOLGA2 HSD3B7 KRTAP10-1 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP9-2 MACO1 NGFR NTM RTN4R SHANK3 SPAG5 TRIM27	13 interacting genes: HOXA1 KEAP1 LINGO1 MAG MGAT5B NEK1 NGFR OMG OTX1 PTK7 RTN4 RTN4IP1 ZDHHC8
Entrez ID		84894	65078
HPRD ID		14322	16123
Ensembl ID		ENSG00000169783	ENSG00000040608
Uniprot IDs		Q96FE5	Q9BZR6
PDB IDs		2ID5 4OQT	1OZN 1P8T
Enriched GO Terms of Interacting Partners?
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