SPSB2 and RECK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPSB2	RECK
Description		splA/ryanodine receptor domain and SOCS box containing 2	reversion inducing cysteine rich protein with kazal motifs
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane Wnt Signalosome
	Molecular Function	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Wnt-protein Binding Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Colorectal cancer ( 26965516) Refractive error ( 32231278)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		12 interacting genes: APP DDX4 FNDC3B GALNT15 NOS2 NRF1 PAWR PRMT1 RECK SMARCD1 TRIM55 TRIM63	44 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL RPS6KA1 SIGMAR1 SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704
Entrez ID		84727	8434
HPRD ID		13610	05567
Ensembl ID		ENSG00000111671	ENSG00000122707
Uniprot IDs		Q99619	A8K9D8 O95980 Q6P9E2
PDB IDs		3EMW 5XN3 6DN5 6DN6 6JKJ 6JWM 6JWN 6KEY
Enriched GO Terms of Interacting Partners?
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