SPSB2 and NRF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPSB2	NRF1
Description		splA/ryanodine receptor domain and SOCS box containing 2	nuclear respiratory factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		Colorectal cancer ( 26965516) Refractive error ( 32231278)	Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)
Interacting Genes		12 interacting genes: APP DDX4 FNDC3B GALNT15 NOS2 NRF1 PAWR PRMT1 RECK SMARCD1 TRIM55 TRIM63	48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC22A18AS SP2 SP4 SPSB2 SRARP TESMIN TEX43 TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6
Entrez ID		84727	4899
HPRD ID		13610	02930
Ensembl ID		ENSG00000111671	ENSG00000106459
Uniprot IDs		Q99619	A0A024R770 A0A024R774 Q16656
PDB IDs		3EMW 5XN3 6DN5 6DN6 6JKJ 6JWM 6JWN 6KEY
Enriched GO Terms of Interacting Partners?
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