CUL4A and DCUN1D4

Number of citations of the paper that reports this interaction (PubMedID 23201271)
45

Data Source:
BioGRID (enzymatic study)

		CUL4A	DCUN1D4
Description		cullin 4A	defective in cullin neddylation 1 domain containing 4
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GO Annotations	Cellular Component	Nucleoplasm Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Ubiquitin Ligase Complex Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Somatic Stem Cell Population Maintenance Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair	Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Neddylation
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Neddylation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Bipolar disorder ( 31043756) Blood protein levels ( 28240269) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intracranial aneurysm ( 30823506) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494 27863252) Red cell distribution width ( 32888494)	Estimated glomerular filtration rate ( 31152163) Familial squamous cell lung carcinoma ( 29924316) Height ( 28552196)
Interacting Genes		25 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 COPS5 CUL4B DCAF6 DCUN1D4 DDB1 DDB2 H1-2 H3C1 HOXA9 IRS2 RBX1 RNF7 SALL2 SENP8 SKP2 ST7 TUBG1 UBC UBE2E3 UBE2M	8 interacting genes: CAND1 CEP135 CUL2 CUL3 CUL4A CUL4B UBE2M VAV2
Entrez ID		8451	23142
HPRD ID		07218	13791
Ensembl ID		ENSG00000139842	ENSG00000109184
Uniprot IDs		A0A0A0MR50 Q13619	B4DH26 Q92564
PDB IDs		2HYE 4A0K	5V89
Enriched GO Terms of Interacting Partners?
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