CUL4A and CENPA

Number of citations of the paper that reports this interaction (PubMedID 25727006)
44

Data Source:
BioGRID (enzymatic study)

		CUL4A	CENPA
Description		cullin 4A	centromere protein A
Image
GO Annotations	Cellular Component	Nucleoplasm Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Nucleosome Inner Kinetochore Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Somatic Stem Cell Population Maintenance Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair	Establishment Of Mitotic Spindle Orientation Mitotic Cytokinesis Kinetochore Assembly Protein Localization To Chromosome, Centromeric Region
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Bipolar disorder ( 31043756) Blood protein levels ( 28240269) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intracranial aneurysm ( 30823506) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494 27863252) Red cell distribution width ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		25 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 COPS5 CUL4B DCAF6 DCUN1D4 DDB1 DDB2 H1-2 H3C1 HOXA9 IRS2 RBX1 RNF7 SALL2 SENP8 SKP2 ST7 TUBG1 UBC UBE2E3 UBE2M	11 interacting genes: AURKB AURKC CDKN2A CUL4A DIAPH1 DIAPH2 H3C3 H4C6 HJURP PARP1 PARP2
Entrez ID		8451	1058
HPRD ID		07218	00313
Ensembl ID		ENSG00000139842	ENSG00000115163
Uniprot IDs		A0A0A0MR50 Q13619	P49450
PDB IDs		2HYE 4A0K	3AN2 3NQJ 3NQU 3R45 3WTP 5CVD 5Z23 6BUZ 6C0W 6E0C 6E0P 6KDQ 6KDS 6L49 6MUO 6MUP 6O1D 6SE0 6SE6 6SEE 6SEF 6SEG 6TEM 7D20
Enriched GO Terms of Interacting Partners?
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