NCALD and IGFBP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NCALD	IGFBP6
Description		neurocalcin delta	insulin like growth factor binding protein 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Clathrin Coat Of Trans-Golgi Network Vesicle	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Tubulin Binding Clathrin Binding Alpha-tubulin Binding	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Vesicle-mediated Transport Calcium-mediated Signaling	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Activation of Ca-permeable Kainate Receptor	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Cerebral amyloid angiopathy ( 25188341) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Coffee consumption ( 21876539) Cognitive performance ( 20125193) Coronary artery disease ( 33020668) Gait speed in old age ( 28077804) LDL peak particle diameter (total fat intake interaction) ( 26112879) Medication use (beta blocking agents) ( 31015401) Microalbuminuria ( 26631737) Perceived sweetness of sucrose ( 31005972) Red cell distribution width ( 32888494) Systolic blood pressure ( 30224653)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)
Interacting Genes		33 interacting genes: ACTB ANOS1 APOL3 C19orf44 C1QTNF2 CLTC CREM DTX2 FGF6 FZD7 GOLGA7 GPX7 IGFBP6 KRT6A LCE2D LIF LITAF LY6G6D MEOX2 MICOS10-NBL1 MIEF2 MLLT10 MYDGF NBL1 PLAAT2 PNP SBSN SPRED1 SRGN TMEM14B TPSG1 TUBA4A TUBB	40 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DDX10 EFEMP1 EFEMP2 ENKD1 EPDR1 ERBB3 GAS8 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Entrez ID		83988	3489
HPRD ID		09466	00902
Ensembl ID		ENSG00000104490	ENSG00000167779
Uniprot IDs		B2RB70 P61601	P24592
PDB IDs			1RMJ
Enriched GO Terms of Interacting Partners?
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