IGFBP6 and C1orf74

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IGFBP6	C1orf74
Description		insulin like growth factor binding protein 6	chromosome 1 open reading frame 74
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex
	Molecular Function	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding	Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)	Alopecia areata ( 25608926)
Interacting Genes		40 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DDX10 EFEMP1 EFEMP2 ENKD1 EPDR1 ERBB3 GAS8 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587	6 interacting genes: C22orf23 IGFBP6 MBD3L1 REL TEKT1 WWTR1
Entrez ID		3489	148304
HPRD ID		00902	08682
Ensembl ID		ENSG00000167779	ENSG00000162757
Uniprot IDs		P24592	A0A0A8K8E6 Q96LT6
PDB IDs		1RMJ
Enriched GO Terms of Interacting Partners?
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