CASP5 and NLRP1

Number of citations of the paper that reports this interaction (PubMedID 12191486)
1786

Data Source:
HPRD (in vitro, in vivo)

		CASP5	NLRP1
Description		caspase 5	NLR family pyrin domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol NLRP1 Inflammasome Complex	Nucleus Nucleoplasm Cytosol Inflammasome Complex NLRP1 Inflammasome Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Double-stranded DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Protein Self-association Cysteine-type Endopeptidase Activator Activity
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Substantia Nigra Development Regulation Of Apoptotic Process Regulation Of Inflammatory Response Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Regulation Of Inflammatory Response Protein Homooligomerization Neuron Apoptotic Process Defense Response To Virus Pyroptosis Self Proteolysis Antiviral Innate Immune Response NLRP1 Inflammasome Complex Assembly
Pathways		Pyroptosis	The NLRP1 inflammasome
Drugs
Diseases
GWAS			Migraine ( 27322543)
Interacting Genes		3 interacting genes: MAX NLRP1 PPHLN1	9 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 NOD1 PYCARD
Entrez ID		838	22861
HPRD ID		04048	07364
Ensembl ID		ENSG00000137757	ENSG00000091592
Uniprot IDs		P51878	Q9C000
PDB IDs			1PN5 3KAT 4IFP 4IM6 5Y3S 6K7V 6XKK
Enriched GO Terms of Interacting Partners?
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