NLRP1 and APAF1

Number of citations of the paper that reports this interaction (PubMedID 17418785)
122

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vivo)

		NLRP1	APAF1
Description		NLR family pyrin domain containing 1	apoptotic peptidase activating factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Inflammasome Complex NLRP1 Inflammasome Complex	Extracellular Region Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Double-stranded DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Protein Self-association Cysteine-type Endopeptidase Activator Activity	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Regulation Of Inflammatory Response Protein Homooligomerization Neuron Apoptotic Process Defense Response To Virus Pyroptosis Self Proteolysis Antiviral Innate Immune Response NLRP1 Inflammasome Complex Assembly	Response To Hypoxia Kidney Development Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Brain Development Aging Response To Nutrient Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cardiac Muscle Cell Apoptotic Process Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway
Pathways		The NLRP1 inflammasome	Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			ATP
Diseases
GWAS		Migraine ( 27322543)	Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		9 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 NOD1 PYCARD	30 interacting genes: ACADS APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CCL13 CDK17 CYCS DZIP1 ELK3 FAS FEM1B HIP1 HNF1A HSP90AA1 HSPA1A MRPL19 NLRP1 NR1H4 NUDT4 PAH PPP1CA RPL26L1 TOP1 TRIAP1 UTP20
Entrez ID		22861	317
HPRD ID		07364	03755
Ensembl ID		ENSG00000091592	ENSG00000120868
Uniprot IDs		Q9C000	O14727
PDB IDs		1PN5 3KAT 4IFP 4IM6 5Y3S 6K7V 6XKK	1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?
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