TLN2 and PIP5K1C

Number of citations of the paper that reports this interaction (PubMedID 12422219)
180

Data Source:
HPRD (in vitro)

		TLN2	PIP5K1C
Description		talin 2	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
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GO Annotations	Cellular Component	Ruffle Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Synapse	Phagocytic Cup Uropod Nucleoplasm Cytosol Adherens Junction Focal Adhesion Endosome Membrane Ruffle Membrane Presynapse
	Molecular Function	Actin Binding Integrin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
	Biological Process	Cytoskeleton Organization Cell-cell Junction Assembly Cell Adhesion Cell-cell Adhesion	Phosphatidylinositol Biosynthetic Process Phagocytosis Regulation Of Phosphatidylinositol 3-kinase Signaling Synaptic Vesicle Exocytosis Phosphorylation Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Phosphatidylinositol Phosphate Biosynthetic Process Synaptic Vesicle Endocytosis Membrane Organization Clathrin-dependent Endocytosis Cell-cell Adhesion
Pathways			Synthesis of PIPs at the plasma membrane SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Body shape index ( 34021172) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Periventricular white matter hyperintensities ( 32517579) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: CLK1 PIP5K1C	18 interacting genes: AKT1 AKT2 AP1B1 AP2B1 ARF6 BTK CDH1 CDK5 HDHD2 ITGB1 LAPTM4B LRP2 NEDD4 PKD1 RPL36 SMURF1 SRC TLN2
Entrez ID		83660	23396
HPRD ID		09555	05834
Ensembl ID		ENSG00000171914	ENSG00000186111
Uniprot IDs		Q9Y4G6	O60331
PDB IDs		6U4K	2G35 3H1Z 3H85
Enriched GO Terms of Interacting Partners?
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