PIP5K1C and PKD1

Number of citations of the paper that reports this interaction (PubMedID 27775029)
6

Data Source:
BioGRID (enzymatic study)

		PIP5K1C	PKD1
Description		phosphatidylinositol-4-phosphate 5-kinase type 1 gamma	polycystin 1, transient receptor potential channel interacting
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GO Annotations	Cellular Component	Phagocytic Cup Uropod Nucleoplasm Cytosol Adherens Junction Focal Adhesion Endosome Membrane Ruffle Membrane Presynapse	Golgi Membrane Polycystin Complex Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Cation Channel Complex Calcium Channel Complex Ciliary Membrane Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity	Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt-activated Receptor Activity Transmembrane Transporter Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Phagocytosis Regulation Of Phosphatidylinositol 3-kinase Signaling Synaptic Vesicle Exocytosis Phosphorylation Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Phosphatidylinositol Phosphate Biosynthetic Process Synaptic Vesicle Endocytosis Membrane Organization Clathrin-dependent Endocytosis Cell-cell Adhesion	Cartilage Condensation In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Wnt Signaling Pathway Peptidyl-serine Phosphorylation Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Response To Fluid Shear Stress Lymph Vessel Morphogenesis Cytoplasmic Sequestering Of Transcription Factor Skin Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Cell Cycle Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Signaling By Wnt Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Synthesis of PIPs at the plasma membrane SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Clathrin-mediated endocytosis	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Dilated cardiomyopathy ( 33677556) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		18 interacting genes: AKT1 AKT2 AP1B1 AP2B1 ARF6 BTK CDH1 CDK5 HDHD2 ITGB1 LAPTM4B LRP2 NEDD4 PKD1 RPL36 SMURF1 SRC TLN2	39 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DDX58 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NADSYN1 NCF1 NCK2 NTHL1 NTN3 OR1F1 PDPK1 PIP5K1C PKD2 PPL PTK2 PTPRG PXN RGS7 RPL3L SIAH1 SOX17 SRC TLN1 VCL VIM
Entrez ID		23396	5310
HPRD ID		05834	03203
Ensembl ID		ENSG00000186111	ENSG00000008710
Uniprot IDs		O60331	P98161
PDB IDs		2G35 3H1Z 3H85	1B4R 6A70
Enriched GO Terms of Interacting Partners?
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