GUCD1 and PTH1R

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GUCD1	PTH1R
Description		guanylyl cyclase domain containing 1	parathyroid hormone 1 receptor
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Receptor Complex
	Molecular Function	Protein Binding	Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Protein Homodimerization Activity Protein Self-association
	Biological Process		Skeletal System Development In Utero Embryonic Development Chondrocyte Differentiation Osteoblast Development Cellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process
Pathways			Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Abaloparatide Parathyroid hormone Teriparatide
Diseases
GWAS		Acne (severe) ( 24927181) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Birth weight ( 31043758 27680694) Hip circumference adjusted for BMI ( 34021172) Microalbuminuria ( 26631737) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 2 diabetes ( 30054458) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		77 interacting genes: ADAM12 ADAMTSL4 APP ATP23 BEGAIN CCDC153 CPSF7 CRX CTAG1A CTAG1B CTH CYSRT1 FCHO1 FHL3 FUCA2 HESX1 HOXA1 HSPB7 ID3 ISCA2 KATNBL1 KPRP KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-5 KRTAP19-6 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-6 KRTAP5-7 KRTAP9-2 KRTAP9-8 LASP1 LCE1C LCE2A LCE2B LCE2D LHX3 LNX1 MAP2K5 MEOX2 MORN3 MORN4 NDUFAF6 NGLY1 PCBD2 PCSK5 PFDN5 PSMA1 PTH1R RSPO4 RUNX3 SLC25A48 SMCP SPRY1 SYNGAP1 TCF4 TEPSIN TFAP2D TOLLIP TRIM42 TSPAN4 TXN2 VASN YPEL3 ZBTB42 ZCCHC13 ZNF250 ZNF655 ZNF705D ZNF835	16 interacting genes: ARRB1 GNB1 GPANK1 GUCD1 HOXA1 MGAT5B MKRN3 PTH PTHLH SLC9A3R1 SLC9A3R2 SMARCC1 STK16 TEKT4 UBC YWHAH
Entrez ID		83606	5745
HPRD ID		12796	01347
Ensembl ID		ENSG00000138867	ENSG00000160801
Uniprot IDs		A0A024R1B8 A0A087WVD9 B4DL90 E7EX77 E9PGZ7 Q7Z629 Q96NT3	A1LPH3 Q03431 Q0VGD7
PDB IDs			1BL1 1ET2 1ET3 3C4M 3H3G 3L2J 4Z8J 5EMB 6NBF 6NBH 6NBI
Enriched GO Terms of Interacting Partners?
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