PTH1R and PTH

Number of citations of the paper that reports this interaction (PubMedID 9108031)
9

Data Source:
HPRD (in vivo)

		PTH1R	PTH
Description		parathyroid hormone 1 receptor	parathyroid hormone
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Protein Homodimerization Activity Protein Self-association	Hormone Activity Protein Binding Parathyroid Hormone Receptor Binding Type 1 Parathyroid Hormone Receptor Binding Protein N-terminus Binding Receptor Ligand Activity Peptide Hormone Receptor Binding
	Biological Process	Skeletal System Development In Utero Embryonic Development Chondrocyte Differentiation Osteoblast Development Cellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process	Skeletal System Development Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Rho Protein Signal Transduction Cell-cell Signaling Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Signal Transduction Response To Lead Ion Regulation Of Gene Expression Negative Regulation Of Gene Expression Magnesium Ion Homeostasis Positive Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Response To Vitamin D Cellular Macromolecule Biosynthetic Process Bone Resorption Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II CAMP Metabolic Process Positive Regulation Of Glucose Import Response To Cadmium Ion Homeostasis Of Number Of Cells Within A Tissue Phosphate Ion Homeostasis Positive Regulation Of Inositol Phosphate Biosynthetic Process Response To Parathyroid Hormone Response To Fibroblast Growth Factor Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Osteoclast Proliferation Negative Regulation Of Bone Mineralization Involved In Bone Maturation
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Abaloparatide Parathyroid hormone Teriparatide	D-norleucine ABX-PTH
Diseases
GWAS		Birth weight ( 31043758 27680694) Hip circumference adjusted for BMI ( 34021172) Microalbuminuria ( 26631737) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 2 diabetes ( 30054458) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bone mineral density ( 19874204) Childhood ear infection ( 27182965) Menarche (age at onset) ( 25231870) Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel ( 28935272)
Interacting Genes		16 interacting genes: ARRB1 GNB1 GPANK1 GUCD1 HOXA1 MGAT5B MKRN3 PTH PTHLH SLC9A3R1 SLC9A3R2 SMARCC1 STK16 TEKT4 UBC YWHAH	7 interacting genes: ASPH BAG6 FEZ1 MEP1A OS9 PTH1R PTH2R
Entrez ID		5745	5741
HPRD ID		01347	01345
Ensembl ID		ENSG00000160801	ENSG00000152266
Uniprot IDs		A1LPH3 Q03431 Q0VGD7	P01270
PDB IDs		1BL1 1ET2 1ET3 3C4M 3H3G 3L2J 4Z8J 5EMB 6NBF 6NBH 6NBI	1BWX 1ET1 1ET2 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG 2L1X 3C4M
Enriched GO Terms of Interacting Partners?
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