NCOA3 and BABAM2

Number of citations of the paper that reports this interaction (PubMedID 21577200)
75

Data Source:
BioGRID (two hybrid)

		NCOA3	BABAM2
Description		nuclear receptor coactivator 3	BRISC and BRCA1 A complex member 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome	Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex
	Molecular Function	RNA Polymerase II Complex Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Nuclear Receptor Coactivator Activity Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Disordered Domain Specific Binding	Peroxisome Targeting Sequence Binding Tumor Necrosis Factor Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Histone Acetylation Cellular Response To Hormone Stimulus Receptor Transactivation Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division	Double-strand Break Repair Chromatin Organization Apoptotic Process Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Signaling Signal Transduction Response To Ionizing Radiation Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)	Blond vs. brown/black hair color ( 30531825) Estimated glomerular filtration rate ( 31152163) Intraocular pressure ( 29617998) Low density lipoprotein cholesterol levels ( 33339817) Urate levels ( 31578528) Uterine fibroids ( 31649266)
Interacting Genes		82 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4-16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SLC22A2 SMARCE1 SPOP SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ	8 interacting genes: BABAM1 GFI1B NCOA3 SHMT2 SUMO2 UBC UBE2D1 VRK2
Entrez ID		8202	9577
HPRD ID		03570	08498
Ensembl ID		ENSG00000124151	ENSG00000158019
Uniprot IDs		Q59EE8 Q9Y6Q9	Q9NXR7
PDB IDs		1KBH 3L3X 3L3Z 6ES7 6SQC	6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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