NCOA3 and NR1H3

Number of citations of the paper that reports this interaction (PubMedID 15604093)
56

Data Source:
HPRD (two hybrid)

		NCOA3	NR1H3
Description		nuclear receptor coactivator 3	nuclear receptor subfamily 1 group H member 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Complex Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Nuclear Receptor Coactivator Activity Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Disordered Domain Specific Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Sterol Response Element Binding
	Biological Process	Histone Acetylation Cellular Response To Hormone Stimulus Receptor Transactivation Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Positive Regulation Of Transporter Activity Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression	PPARA activates gene expression VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs			TO-901317 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Diacerein Rhein
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood glucose levels ( 31928498) Creatinine levels ( 29403010) Feeling miserable ( 29500382) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 19060910 20686565) Hypertension ( 31879980) Intraocular pressure ( 29785010) Lymphocyte percentage of white cells ( 27863252) Metabolic syndrome ( 22399527) Monocyte percentage of white cells ( 27863252) Mood instability ( 31168069) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Triglyceride levels ( 32154731) Triglycerides ( 30275531)
Interacting Genes		82 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4-16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SLC22A2 SMARCE1 SPOP SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ	35 interacting genes: ACTN1 APP BAG3 CEP350 EDF1 FOXO3 GPANK1 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA PPARD PPARG PSMC5 RARA RXRA RXRB RXRG SIRT1 SS18L1 SUV39H1 SYT1 TMEM161A UBE2I ZXDC
Entrez ID		8202	10062
HPRD ID		03570	07211
Ensembl ID		ENSG00000124151	ENSG00000025434
Uniprot IDs		Q59EE8 Q9Y6Q9	B4DXU5 B5MBY7 F1D8N1 Q13133
PDB IDs		1KBH 3L3X 3L3Z 6ES7 6SQC	1UHL 3IPQ 3IPS 3IPU 5AVI 5AVL 5HJS
Enriched GO Terms of Interacting Partners?
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