CLPP and TNPO3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CLPP	TNPO3
Description		caseinolytic mitochondrial matrix peptidase proteolytic subunit	transportin 3
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Endopeptidase Clp Complex	Nuclear Envelope Annulate Lamellae Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Endopeptidase Activity ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Identical Protein Binding ATPase Binding	Protein Binding Small GTPase Binding Identical Protein Binding Nuclear Import Signal Receptor Activity
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Membrane Protein Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process	Protein Import Into Nucleus
Pathways
Drugs		N-Formylmethionine
Diseases
GWAS			Diffuse cutaneous systemic sclerosis ( 29293537) Limited cutaneous systemic scleroderma ( 29293537) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 20639880) Primary biliary cirrhosis ( 22961000) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 18204446 24871463 26606652 23053960 26502338 18204098 32771030 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 21750679 31672989 30247649 29293537) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Ulcerative colitis ( 23128233 21297633)
Interacting Genes		19 interacting genes: ABI2 C14orf119 CHCHD3 CLPX DTX2 EFEMP1 EFEMP2 GRN KRTAP10-1 NUTF2 P4HA3 PLSCR4 PPP2CA PSMB1 RBPMS STAT4 TNFSF9 TNPO3 TRIM54	19 interacting genes: BLMH CAMK2B CAMK2D CAMK2G CHMP3 CLPP ECI2 GCH1 ICA1L KRT75 KRTAP10-8 MEOX2 NME1 PPP1R1C SMURF2 SRSF1 SSX2 SSX2B TRA2B
Entrez ID		8192	23534
HPRD ID		03074	18209
Ensembl ID		ENSG00000125656	ENSG00000064419
Uniprot IDs		Q16740	A0A024R794 B3KMX1 Q9Y5L0
PDB IDs		1TG6 6BBA 6DL7 6H23	4C0O 4C0P 4C0Q 4OL0 6GX9
Enriched GO Terms of Interacting Partners?
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