SHARPIN and FMR1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		SHARPIN	FMR1
Description		SHANK associated RH domain interactor	FMRP translational regulator 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Dendrite LUBAC Complex	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Chromocenter Cytoplasmic Stress Granule Postsynaptic Density Cajal Body Membrane Extrinsic Component Of Plasma Membrane Axon Dendrite Growth Cone Filopodium Tip Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Dendritic Spine Neck Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Ribonucleoprotein Granule Glial Cell Projection Presynapse Postsynapse Dendritic Filopodium Messenger Ribonucleoprotein Complex Growth Cone Filopodium Ribonucleoprotein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding	G-quadruplex RNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Poly(U) RNA Binding Translation Repressor Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Poly(G) Binding Methylated Histone Binding SiRNA Binding MiRNA Binding RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Transmembrane Transporter Binding Translation Regulator Activity Protein Heterodimerization Activity MRNA 5'-UTR Binding Dynein Complex Binding Sequence-specific MRNA Binding
	Biological Process	Mitochondrion Organization Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Internalization MRNA Processing Cellular Response To DNA Damage Stimulus Glutamate Receptor Signaling Pathway Nervous System Development RNA Splicing Negative Regulation Of Translation Gene Silencing By RNA Positive Regulation Of Histone Phosphorylation Cellular Response To UV Regulation Of MRNA Stability Modulation By Host Of Viral RNA Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Neurotransmitter Secretion MRNA Transport Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Regulation Of Gene Silencing By MiRNA Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Development Cellular Response To Hydroxyurea Cellular Response To Virus Regulation Of Neuronal Action Potential Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Binding Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Gene Silencing By MiRNA Negative Regulation Of Cytoplasmic Translation Positive Regulation Of Response To DNA Damage Stimulus
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins
Drugs
Diseases
GWAS		Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Fragile X syndrome ( 30531935)
Interacting Genes		24 interacting genes: ACTR2 ACTR3 FMR1 FXR1 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 SHANK1 SHANK2 SHANK3 TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32	48 interacting genes: AKAP9 ALDOC ATG5 BEX4 CALCOCO2 CAMK2B CASK CCAR2 CWC25 CYFIP1 CYFIP2 DCTPP1 DGKD EFHC1 FSD2 FXR1 FXR2 GRIP2 HOMER3 INCA1 LIMS1 MAGI3 MEOX1 MVP NCL NECAB2 NUFIP1 NUFIP2 PICK1 POLR1C PPP1R12C PSME3 RANBP9 RBM14 SF3B2 SFPQ SHARPIN SPAG5 SRC STAU1 SUOX TACC2 UBE2I WBP2NL YBX1 ZBTB42 ZFPM2 ZMYND8
Entrez ID		81858	2332
HPRD ID		15463	02398
Ensembl ID		ENSG00000179526	ENSG00000102081
Uniprot IDs		Q6PJD5 Q9H0F6	Q06787
PDB IDs		4EMO 5X0W	2BKD 2FMR 2LA5 2QND 4OVA 4QVZ 4QW2 5DE5 5DE8 5DEA 5UWJ 5UWO
Enriched GO Terms of Interacting Partners?
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