FMR1 and DCTPP1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		FMR1	DCTPP1
Description		FMRP translational regulator 1	dCTP pyrophosphatase 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Chromocenter Cytoplasmic Stress Granule Postsynaptic Density Cajal Body Membrane Extrinsic Component Of Plasma Membrane Axon Dendrite Growth Cone Filopodium Tip Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Dendritic Spine Neck Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Ribonucleoprotein Granule Glial Cell Projection Presynapse Postsynapse Dendritic Filopodium Messenger Ribonucleoprotein Complex Growth Cone Filopodium Ribonucleoprotein Complex	Nucleus Mitochondrion Cytosol
	Molecular Function	G-quadruplex RNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Poly(U) RNA Binding Translation Repressor Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Poly(G) Binding Methylated Histone Binding SiRNA Binding MiRNA Binding RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Transmembrane Transporter Binding Translation Regulator Activity Protein Heterodimerization Activity MRNA 5'-UTR Binding Dynein Complex Binding Sequence-specific MRNA Binding	Magnesium Ion Binding Protein Binding Pyrimidine Deoxyribonucleotide Binding Identical Protein Binding Nucleoside-triphosphate Diphosphatase Activity DCTP Diphosphatase Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Internalization MRNA Processing Cellular Response To DNA Damage Stimulus Glutamate Receptor Signaling Pathway Nervous System Development RNA Splicing Negative Regulation Of Translation Gene Silencing By RNA Positive Regulation Of Histone Phosphorylation Cellular Response To UV Regulation Of MRNA Stability Modulation By Host Of Viral RNA Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Neurotransmitter Secretion MRNA Transport Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Regulation Of Gene Silencing By MiRNA Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Development Cellular Response To Hydroxyurea Cellular Response To Virus Regulation Of Neuronal Action Potential Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Binding Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Gene Silencing By MiRNA Negative Regulation Of Cytoplasmic Translation Positive Regulation Of Response To DNA Damage Stimulus	DCTP Catabolic Process Nucleoside Triphosphate Catabolic Process DNA Protection DTTP Catabolic Process
Pathways			Interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Fragile X syndrome ( 30531935)	Urinary sodium excretion ( 31409800)
Interacting Genes		48 interacting genes: AKAP9 ALDOC ATG5 BEX4 CALCOCO2 CAMK2B CASK CCAR2 CWC25 CYFIP1 CYFIP2 DCTPP1 DGKD EFHC1 FSD2 FXR1 FXR2 GRIP2 HOMER3 INCA1 LIMS1 MAGI3 MEOX1 MVP NCL NECAB2 NUFIP1 NUFIP2 PICK1 POLR1C PPP1R12C PSME3 RANBP9 RBM14 SF3B2 SFPQ SHARPIN SPAG5 SRC STAU1 SUOX TACC2 UBE2I WBP2NL YBX1 ZBTB42 ZFPM2 ZMYND8	22 interacting genes: APP ARMC5 FMR1 FXR1 FXR2 GDPD3 LNX1 NIF3L1 NOA1 NTAQ1 PAGR1 PRR14 PSMA1 RUSF1 SDCBP SLX1B SPG21 USP7 VKORC1 ZNF668 ZNF747 ZNF768
Entrez ID		2332	79077
HPRD ID		02398	18310
Ensembl ID		ENSG00000102081	ENSG00000179958
Uniprot IDs		Q06787	Q9H773
PDB IDs		2BKD 2FMR 2LA5 2QND 4OVA 4QVZ 4QW2 5DE5 5DE8 5DEA 5UWJ 5UWO
Enriched GO Terms of Interacting Partners?
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