AMN and MTA1

		AMN	MTA1
Description		amnion associated transmembrane protein	metastasis associated 1
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Clathrin-coated Pit Endosome Membrane Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Protein-containing Complex Extracellular Exosome	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Microtubule NuRD Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Signaling Receptor Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Receptor-mediated Endocytosis Excretion Protein Localization Cobalamin Transport Golgi To Plasma Membrane Protein Transport	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Signal Transduction Response To Ionizing Radiation Histone Deacetylation Circadian Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Autoubiquitination
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective CUBN causes hereditary megaloblastic anemia 1 HDL clearance	HDACs deacetylate histones SUMOylation of transcription factors ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs		Hydroxocobalamin
Diseases
GWAS		Body mass index ( 26426971)	Heel bone mineral density ( 30598549)
Interacting Genes		4 interacting genes: CDC42BPB MTA1 STAMBP TECPR2	46 interacting genes: AMN BCL11A BLOC1S1 CCNH CSNK1G2 CYSRT1 DDX18 DYNLL1 E2F1 ERCC6 ESR1 FHL3 GPR183 GRB2 H3-4 HDAC1 HDAC2 HIF1A ITGB3BP JUN KHDRBS2 KPNA4 KRT31 KRT40 KRTAP10-8 LMO4 LRRK2 LZTS2 MAGEA11 MBD3L2 MNAT1 NACC2 NBPF19 NELFCD NOTCH2NLA PICK1 PLEKHG4 RBBP4 SAT1 SH3GL1 SH3GLB1 SUMO2 TEX11 TP53 TRIM25 UBE2I
Entrez ID		81693	9112
HPRD ID		09314	04633
Ensembl ID		ENSG00000166126	ENSG00000182979
Uniprot IDs		B3KP64 Q9BXJ7	Q13330 Q9BRL8
PDB IDs		6GJE	4BKX 4PBY 4PBZ 4PC0 5FXY 5ICN 6G16 6ZRC 7AO8 7AO9 7AOA
Enriched GO Terms of Interacting Partners?
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