AKAP1 and PRKAR1A

Number of citations of the paper that reports this interaction (PubMedID 9065479)
89

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		AKAP1	PRKAR1A
Description		A-kinase anchoring protein 1	protein kinase cAMP-dependent type I regulatory subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Membrane	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Sperm Connecting Piece Ciliary Base Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding Protein Kinase A Regulatory Subunit Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Apoptotic Process Antiviral Innate Immune Response	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Female Meiotic Nuclear Division Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Mitochondrial calcium ion transport Factors involved in megakaryocyte development and platelet production	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production
Drugs			(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Crohn's disease ( 26192919) Freckles ( 29895819) Inflammatory bowel disease ( 26192919) Male-pattern baldness ( 27182965)	Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		12 interacting genes: AMY1A CAV1 CFAP91 DYSF MYCBP PPP1CA PRKACA PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPN21	47 interacting genes: AKAP1 AKAP10 AKAP11 AKAP4 AKAP5 AKAP7 ARFGEF2 BAHD1 C11orf49 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SPART TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		8165	5573
HPRD ID		03905	01786
Ensembl ID		ENSG00000121057	ENSG00000108946
Uniprot IDs		A0A140VK05 B4DN86 Q92667	B2R5T5 P10644
PDB IDs			5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?
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