TDRD3 and TOP3A

Number of citations of the paper that reports this interaction (PubMedID 28176834)
8

Data Source:
BioGRID (x-ray crystallography, pull down)

		TDRD3	TOP3A
Description		tudor domain containing 3	DNA topoisomerase III alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Cytosol	Nucleus Nucleoplasm Chromosome Mitochondrial Matrix PML Body
	Molecular Function	Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding Methylated Histone Binding	DNA Binding Single-stranded DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Zinc Ion Binding
	Biological Process	Chromatin Organization Positive Regulation Of Transcription, DNA-templated	DNA Topological Change Mitochondrial DNA Metabolic Process Chromosome Separation Meiotic Cell Cycle
Pathways			HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Breast size ( 22747683) Menopause (age at onset) ( 22267201 26414677) Verbal declarative memory ( 25648963)	Systolic blood pressure ( 30224653)
Interacting Genes		6 interacting genes: FUS H3-4 POLR2A TOP3A UBC USP9X	3 interacting genes: BLM RECQL5 TDRD3
Entrez ID		81550	7156
HPRD ID		11625	03145
Ensembl ID		ENSG00000083544	ENSG00000177302
Uniprot IDs		A0A024QZE0 Q9H7E2	B4DSJ0 Q13472
PDB IDs		1WJI 2LTO 3PMT 3PNW 3S6W 5GVD 5GVE 5YJ8 6V9T	4CGY 4CHT
Enriched GO Terms of Interacting Partners?
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