TOP3A and RECQL5

Number of citations of the paper that reports this interaction (PubMedID 10710432)
49

Data Source:
HPRD (in vitro, in vivo)

		TOP3A	RECQL5
Description		DNA topoisomerase III alpha	RecQ like helicase 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Mitochondrial Matrix PML Body	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol RNA Polymerase II, Holoenzyme
	Molecular Function	DNA Binding Single-stranded DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Zinc Ion Binding	RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Helicase Activity ATP Binding Four-way Junction Helicase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity
	Biological Process	DNA Topological Change Mitochondrial DNA Metabolic Process Chromosome Separation Meiotic Cell Cycle	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cell Division Chromosome Separation Cellular Response To Xenobiotic Stimulus Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Systolic blood pressure ( 30224653)	Deep white matter hyperintensities ( 32517579) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		3 interacting genes: BLM RECQL5 TDRD3	21 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PCNA PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B
Entrez ID		7156	9400
HPRD ID		03145	04806
Ensembl ID		ENSG00000177302	ENSG00000108469
Uniprot IDs		B4DSJ0 Q13472	A0A024R8M9 A0A024R8S8 B3KQK2 O94762 Q8WYH5
PDB IDs		4CGY 4CHT	4BK0 5LB3 5LB5 5LB8 5LBA
Enriched GO Terms of Interacting Partners?
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