USP5 and TRIM26

Number of citations of the paper that reports this interaction (PubMedID 23105109)
19

Data Source:
BioGRID (two hybrid)

		USP5	TRIM26
Description		ubiquitin specific peptidase 5	tripartite motif containing 26
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Lysosome Cytosol	Cellular_component Nucleus Cytoplasm Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Zinc Ion Binding Ubiquitin Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination	Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell
Pathways		Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes	Interferon gamma signaling
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) General cognitive ability ( 29844566) Hematocrit ( 32888494) LDL cholesterol levels ( 32203549) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Neuroticism ( 29255261) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 21926974 22883433 30285260) Squamous cell lung carcinoma ( 28604730) Triglyceride levels ( 32203549) Waist-hip index ( 34021172)
Interacting Genes		26 interacting genes: APP DAZAP2 DVL2 METTL3 PJA1 PLA2G2A RFFL RNF11 RNF216 SPART STK33 SUMO2 TADA3 TMEM239 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIML1 UBC UBE2S UBTD2 USP28	28 interacting genes: BEND7 BIVM DDX41 EPN2 EPN3 INCA1 IRF3 LMNA MACROH2A1 MAGEA6 MIR138-2 MIR18B MNAT1 OTUB2 PHF7 RABEP1 RNF10 RNF126 SUMO2 THAP1 TLE5 TRIM41 UBE2D1 UBE2D2 UBE2D3 USP36 USP39 USP5
Entrez ID		8078	7726
HPRD ID		03265	02901
Ensembl ID		ENSG00000111667	ENSG00000234127
Uniprot IDs		A0A140VJZ1 P45974	A0A024RCP3 Q12899
PDB IDs		2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G
Enriched GO Terms of Interacting Partners?
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