USP5 and METTL3

Number of citations of the paper that reports this interaction (PubMedID 33217317)
5

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		USP5	METTL3
Description		ubiquitin specific peptidase 5	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
Image
GO Annotations	Cellular Component	Nucleus Lysosome Cytosol	Nucleus Nucleoplasm Cytoplasm Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Zinc Ion Binding Ubiquitin Binding	MRNA (N6-adenosine)-methyltransferase Activity MRNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity MRNA (2'-O-methyladenosine-N6-)-methyltransferase Activity Protein Heterodimerization Activity S-adenosyl-L-methionine Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination	MRNA Splicing, Via Spliceosome RNA Methylation Adenosine To Inosine Editing MRNA Processing MRNA Catabolic Process Cellular Response To DNA Damage Stimulus Spermatogenesis Circadian Rhythm Dosage Compensation By Inactivation Of X Chromosome Stem Cell Population Maintenance Forebrain Radial Glial Cell Differentiation Primary MiRNA Processing Cellular Response To UV Gliogenesis Innate Immune Response Regulation Of T Cell Differentiation Positive Regulation Of Translation Negative Regulation Of Notch Signaling Pathway Oogenesis Regulation Of Meiotic Cell Cycle Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization MRNA Methylation Endothelial To Hematopoietic Transition Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Cap-independent Translational Initiation Primary MiRNA Methylation
Pathways		Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes	Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Response to Homoharringtonine (cytotoxicity) ( 25628645)
Interacting Genes		26 interacting genes: APP DAZAP2 DVL2 METTL3 PJA1 PLA2G2A RFFL RNF11 RNF216 SPART STK33 SUMO2 TADA3 TMEM239 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIML1 UBC UBE2S UBTD2 USP28	9 interacting genes: EIF3G EIF3I EIF3J EIF3M MAPK1 MAPK14 MAPK8 MTDH USP5
Entrez ID		8078	56339
HPRD ID		03265	14389
Ensembl ID		ENSG00000111667	ENSG00000165819
Uniprot IDs		A0A140VJZ1 P45974	Q86U44
PDB IDs		2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G	5IL0 5IL1 5IL2 5K7M 5K7U 5K7W 5L6D 5L6E 5TEY 5YZ9 6TTP 6TTT 6TTV 6TTW 6TTX 6TU1 6Y4G 7ACD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?