CUL5 and PTPN5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CUL5	PTPN5
Description		cullin 5	protein tyrosine phosphatase non-receptor type 5
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GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage	Nucleoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERBB2 Signaling Pathway Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation	Interleukin-37 signaling
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Myopia ( 27182965) Refractive error ( 32231278)
Interacting Genes		38 interacting genes: ANAPC11 ASB11 CCNB1IP1 CCNDBP1 COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DDX10 DEPTOR ELOA ELOC ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBC UBE2F VHL	22 interacting genes: CCNQ CLEC4G CUL5 CXCL9 CYB561D2 ENTPD3 FCER1G FYN MAPK1 MAPK3 MARCHF5 MOB1A PLS3 PRKN SAAL1 SLC35B1 SNX4 TERF1 TMEM201 TMEM51 VTI1B ZBTB5
Entrez ID		8065	84867
HPRD ID		03444	01472
Ensembl ID		ENSG00000166266	ENSG00000110786
Uniprot IDs		Q93034	B7Z2F8 P54829 Q86TL3
PDB IDs		3DPL 3DQV 4JGH 4N9F 6V9I	2BIJ 2BV5 2CJZ 5OVR 5OVX 5OW1 6H8R
Enriched GO Terms of Interacting Partners?
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