SEMA6D and PLXNA1

Number of citations of the paper that reports this interaction (PubMedID 14977921)
106

Data Source:
HPRD (in vivo)

		SEMA6D	PLXNA1
Description		semaphorin 6D	plexin A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane	Semaphorin Receptor Complex Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Semaphorin Receptor Binding Chemorepellent Activity	Semaphorin Receptor Activity Signaling Receptor Activity
	Biological Process	Neural Crest Cell Migration Axon Guidance Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Migration Ventricular System Development Positive Regulation Of Cell Migration Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Semaphorin-plexin Signaling Pathway	Negative Regulation Of Cell Adhesion Multicellular Organism Development Regulation Of Cell Shape Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Neuron Projection Extension
Pathways		Other semaphorin interactions	Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions RHOD GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Antisaccade task score ( 31596458) Attention deficit hyperactivity disorder ( 29325848) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Attention deficit hyperactivity disorder or intracranial volume (pleiotropy) ( 30818988) Attention deficit hyperactivity disorder or putamen volume (pleiotropy) ( 30818988) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Carotid plaque burden (smoking interaction) ( 24954085) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcification ( 23870195) Cuneus cortex volume ( 31530798) Diisocyanate-induced asthma ( 25918132) Eating disorders ( 22911880) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hair greying ( 26926045) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28008999) Lack of perseverance ( 30718321) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung cancer ( 28604730) Lung function (FVC) ( 30061609) Neurociticism ( 29500382) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Oily fish consumption ( 32066663) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Pericalcarine cortex volume ( 31530798) Phoneme awareness ( 30741946) Pork consumption ( 32066663) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to radiotherapy in cancer (late toxicity) ( 24785509) Restless legs syndrome ( 29029846) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (current vs never) ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28008999)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576 29875488) Platelet count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 31469255) Weight ( 28552196) Whole-brain volume ( 21116278)
Interacting Genes		5 interacting genes: BLOC1S6 C15orf48 PLXNA1 SHF SPATA5L1	10 interacting genes: AKT1 FES FGFR2 L1CAM NRP1 NRP2 PLXNB1 RHOD RND1 SEMA6D
Entrez ID		80031	5361
HPRD ID		10221	11868
Ensembl ID		ENSG00000137872	ENSG00000114554
Uniprot IDs		A0A185QE25 Q8NFY4	Q9UIW2
PDB IDs
Enriched GO Terms of Interacting Partners?
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