JADE1 and HMOX2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		JADE1	HMOX2
Description		jade family PHD finger 1	heme oxygenase 2
Image		No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome Cytoplasm Plasma Membrane Nuclear Speck Ciliary Basal Body	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Metal Ion Binding	Heme Oxygenase (decyclizing) Activity Protein Binding Heme Binding Metal Ion Binding
	Biological Process	Apoptotic Process Negative Regulation Of Cell Growth Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Response To Hypoxia Heme Oxidation Response To Oxidative Stress Heme Catabolic Process Iron Ion Homeostasis
Pathways		HATs acetylate histones	Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1
Drugs			NADH Stannsoporfin
Diseases
GWAS		Arterial stiffness index ( 31235810) Bone mineral density (total hip) ( 29883787)	Erectile dysfunction ( 30583798)
Interacting Genes		16 interacting genes: AKT1 AP2M1 CTNNB1 H3C14 H4C1 HMOX2 PFDN1 SEPTIN8 SMN1 TK1 UBE2E1 UBE2H UBE3A VHL YJU2 ZNF148	66 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LRIF1 MARK3 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746
Entrez ID		79960	3163
HPRD ID		10151	00783
Ensembl ID		ENSG00000077684	ENSG00000103415
Uniprot IDs		B4E2E2 Q6IE81	A0A087WT44 B3KSE0 P30519
PDB IDs			2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?
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